Codonopsis 蔓蔘
Pharmaceutical nameCodonopsis Pilosulae Radix
The three axes are assessed independently and are never combined into a single score.
KTKP records the origin species as Codonopsis pilosulae (Fr.) Nannf.. It has not yet been cross-checked against the Korean Pharmacopoeia, so the identification confidence is not raised to an official code mapping. The name most used for this taxon in current literature is Codonopsis pilosula. Literature searches for this herb also cover Codonopsis pilosulae — the same taxon appears under several names. The nomenclatural discussion for this herb was flagged for correction during verification; only the verified facts are shown here, with the details in docs/HERB_NAME_RESEARCH.md.
Tradition · what the text describes
탕액편
The sub-section within this volume has not been verified against the original text yet.
The KTKP traditional materia medica record (M0000824) gives the origin species as Codonopsis pilosulae (Fr.) Nannf., the part used as 뿌리, and the properties as 감(甘), 무독(無毒), 평(平). It lists 비(脾), 폐(肺) as the channels entered.
Properties & channel entry: 감(甘), 무독(無毒), 평(平) · 비(脾), 폐(肺)
Source species: Codonopsis pilosulae (Fr.) Nannf. (뿌리)
Modern · documented evidence
(no indication derived — herb-name-only search)evidence for this indication
- No indication is specified. A and B grades cannot be assigned until the query is narrowed to a specific indication.
- No indication could be derived: no condition appears on two or more registered trials for this herb.
Literature
SR 6 · RCT 12 · preclinical 169
These counts come from a herb-name-only search (6 systematic reviews, 12 RCTs). Without a specific indication they show how much the herb has been studied, not what it works for.
Query used
We publish the exact query behind these counts so you can reproduce them yourself.
SRC:MED AND ((TITLE_ABS:"Codonopsis pilosula") OR (TITLE_ABS:"Codonopsis pilosulae"))- Structural Characterization and Immunomodulatory Activity of Fructan Polysaccharides from Two Varieties of Codonopsis pilosulae (C. pilosula Nannf. var. modesta and C. pilosula (Franch.) Nannf.). (2026 · research-article; Journal Article)
- Codonopsis pilosula as the sovereign herb in Shenling Baizhu formula ameliorates DSS-induced ulcerative colitis via spermidine-AMPK-mediated mitophagy to inhibit the cGAS-STING inflammatory axis. (2026 · Journal Article)
- A comprehensive review on the polysaccharides derived from Codonopsis pilosula: Extraction, isolation and purification, structural characteristics, biological activities, structure-activity relationships, toxicity, and development and utilization. (2026 · Review; Journal Article)
- Exploring the antidepressant mechanism of Codonopsis pilosula through network pharmacology and molecular docking analysis. (2026 · Journal Article)
- Luteolin and glycitein from Codonopsis pilosula ameliorate age-related locomotor decline in C. elegans via DAF-16-dependent but autophagy-divergent pathways. (2026 · Journal Article)
- Corrigendum to "Codonopsis pilosula (Dangshen) decoction promotes NR2F2-dependent pulmonary endothelial repair in an H9N2-induced lung injury model" [J. Ethnopharmacol. 370 (2026) 122078]. (2026 · Published Erratum)
- Codonopsis pilosula Polysaccharide (CPP) Alleviates D-Gal-Induced Aging and Gut Microbiota Dysbiosis. (2026 · research-article; Journal Article)
- Codonopsis pilosula (2006 · Review)
- Codonopsis pilosula polysaccharides in intestinal flora and intestinal homeostasis: A review. (2026 · Review; Journal Article)
- Enhancement of Bioactive Compounds and Antioxidant Properties in Codonopsis pilosula Through Extrusion Processing and Development of Codonopsis-Oat Powder. (2025 · research-article; Journal Article)
Clinical trials
- NCT07320937 — ENROLLING_BY_INVITATION · NA
- NCT02616952 — COMPLETED · PHASE2
- NCT05613465 — UNKNOWN · NA
- NCT06674252 — RECRUITING · NA
- NCT04601792 — UNKNOWN · PHASE4
- NCT03186625 — UNKNOWN · NA
- NCT06980636 — RECRUITING · PHASE4
- NCT03002090 — COMPLETED · NA
- NCT06266559 — UNKNOWN · NA
- NCT03177889 — UNKNOWN · NA
Safety
auto-proposed · unreviewed
- 8 adverse-event or toxicity record(s) were found. This only flags that literature exists — read the abstracts to decide between "caution" and "harm confirmed".
- The KTKP record states the following traditional contraindication: 사실(邪實)인 경우 특히 중만자(中滿者)에 기(忌)하며 여로(藜蘆)와는 상반(相反)하며 오령지(五靈脂)와는 상살(相殺)한다.
Adverse-event and toxicity literature
This is not a finding of harm — it lists literature that is retrievable. Read the papers to decide.
- A Heterogeneous Codonopsis pilosula Polysaccharide Preparation Attenuates Doxorubicin-Induced Cardiotoxicity in Mice: Associations with Oxidative Stress, Mitochondrial Function, and Gut Microbiota. (2026 · Journal Article)
- Protective effects of polysaccharides derived from Panax ginseng and Codonopsis pilosula against doxorubicin-induced myocardial senescence. (2026 · Journal Article)
- Codonopsis pilosula polysaccharides (CPP) intervention alleviates sterigmatocystin (STC)-induced liver injury and gut microbiota dysbiosis. (2024 · Journal Article)
- An Inulin-Type Fructan CP-A from Codonopsis pilosula Alleviated 5-Fluorouracil-Induced Intestinal Mucositis via the ERK/MLCK/MLC2 Pathway and Regulation of Gut Microbiota. (2024 · research-article; Journal Article)
- Efficacy and safety of medicine-food homology Shenqi paste in older adults with diabetic sarcopenia: A randomized, double-blind, placebo-controlled trial. (2026 · Randomized Controlled Trial; Journal Article)