Coptis 黃連
Pharmaceutical nameCoptidis Rhizoma
The three axes are assessed independently and are never combined into a single score.
KTKP records the origin species as Coptis chinensis Franch. It has not yet been cross-checked against the Korean Pharmacopoeia, so the identification confidence is not raised to an official code mapping. The same drug appears under 2 records as name variants. The same source species also yields 1 other separately registered drug(s) (Alcohol cum Coptidis Rhizoma), which must not be conflated. The name most used for this taxon in current literature is Coptis chinensis.
Tradition · what the text describes
탕액편
The sub-section within this volume has not been verified against the original text yet.
The KTKP traditional materia medica record (M0004374) gives the origin species as Coptis chinensis Franch, the part used as 뿌리줄기, and the properties as 고(苦), 무독(無毒), 한(寒). It lists 간(肝), 대장(大腸), 심(心), 위(胃) as the channels entered. The same record cites the Donguibogam (1613) as the source for its indications.
Properties & channel entry: 고(苦), 무독(無毒), 한(寒) · 간(肝), 대장(大腸), 심(心), 위(胃)
Source species: Coptis chinensis Franch (뿌리줄기)
Modern · documented evidence
Alzheimer Diseaseevidence for this indication
- 2 registered trial(s) exist but no published systematic review or RCT was found. Check whether the research is ongoing or simply unpublished.
- The indication was derived automatically from the Condition field of 2 registered trial(s). It reflects what is currently being studied, not a traditional use, and a curator should confirm the label is apt.
Literature
SR 0 · RCT 0 · preclinical 0
No human studies were found within the sources searched. This means "not yet studied", not "does not work".
Query used
We publish the exact query behind these counts so you can reproduce them yourself.
SRC:MED AND ((TITLE_ABS:"Coptis chinensis")) AND TITLE_ABS:"Alzheimer Disease"Clinical trials
- NCT07768579 — RECRUITING
- NCT03221894 — COMPLETED
Chronic Insomniaevidence for this indication
- 2 registered trial(s) exist but no published systematic review or RCT was found. Check whether the research is ongoing or simply unpublished.
- The indication was derived automatically from the Condition field of 2 registered trial(s). It reflects what is currently being studied, not a traditional use, and a curator should confirm the label is apt.
Literature
SR 0 · RCT 0 · preclinical 0
No human studies were found within the sources searched. This means "not yet studied", not "does not work".
Query used
We publish the exact query behind these counts so you can reproduce them yourself.
SRC:MED AND ((TITLE_ABS:"Coptis chinensis")) AND TITLE_ABS:"Chronic Insomnia"Clinical trials
- NCT06467851 — COMPLETED · NA
- NCT05452577 — COMPLETED · NA
Safety
auto-proposed · unreviewed
- 17 adverse-event or toxicity record(s) were found. This only flags that literature exists — read the abstracts to decide between "caution" and "harm confirmed".
- 2 interaction-related record(s) are retrievable. This flags that literature exists — it is not an interaction checker (§3.4).
- The KTKP record states the following traditional contraindication: 고한(苦寒)으로 상위(傷胃)시키므로 비위(脾胃)가 허한(虛寒)하고 실화(實火)가 있지 않으면 응용하여서는 안된다. 즉 위한구토(胃寒嘔吐)와 비허설사(脾虛泄瀉)의 증(證)에는 복용을 기(忌)하고, 과양(過量)이나 구복(久服)은 마땅하지 않다.
Adverse-event and toxicity literature
This is not a finding of harm — it lists literature that is retrievable. Read the papers to decide.
- Coptis chinensis Franch. Suppresses Invasive Pulmonary Aspergillosis by Augmenting NADPH-Dependent Neutrophil Extracellular Traps via Dual Modulation of Complement Activation and Gut Microbiota. (2026 · research-article; Journal Article)
- Randomized, Double-Blind, Multicenter, Phase 3 Study of AG NPP709 Compared With Ivy Leaf Extract in Patients With Acute or Chronic Respiratory Symptoms. (2026 · Clinical Trial, Phase III; Equivalence Trial; research-article; Multicenter Study; Randomized Controlled Trial; Journal Article)
- Discovering the compatibility of Coptidis Rhizoma and Gardeniae Fructus in attenuating hepatotoxicity through the association rules analysis of related formula. (2025 · Journal Article)
- Coptisine, the Characteristic Constituent from Coptis chinensis, Exhibits Significant Therapeutic Potential in Treating Cancers, Metabolic and Inflammatory Diseases. (2023 · Review; Journal Article)
- Harder, better, faster, stronger? Retrospective chart review of adverse events of interactions between adaptogens and antidepressant drugs. (2023 · research-article; Journal Article)
Interaction literature
This lists literature that is retrievable — it is not a judgement that an interaction exists. Read the papers to decide.
- Herb-Drug Interactions and Their Impact on Pharmacokinetics: An Update. (2023 · Review; Journal Article)
- San-Huang-Xie-Xin-Tang Constituents Exert Drug-Drug Interaction of Mutual Reinforcement at Both Pharmacodynamics and Pharmacokinetic Level: A Review. (2016 · review-article; Review; Journal Article)
Sources
- KTKP materia medica (15002148) (fetched 2026-08-27)
- Europe PMC REST (fetched 2026-08-28)
- ClinicalTrials.gov API v2 (fetched 2026-08-28)
- Europe PMC REST (fetched 2026-08-28)
- ClinicalTrials.gov API v2 (fetched 2026-08-28)
- KTKP materia medica (15002148) (fetched 2026-08-27)
- Europe PMC REST (fetched 2026-08-28)