Motherwort 益母草
Pharmaceutical nameLeonuri Herba
The three axes are assessed independently and are never combined into a single score.
KTKP records the origin species as Leonurus japonicus Houtt.. It has not yet been cross-checked against the Korean Pharmacopoeia, so the identification confidence is not raised to an official code mapping. The same drug appears under 3 records as name variants. The name most used for this taxon in current literature is Leonurus japonicus. Literature searches for this herb also cover Leonurus heterophyllus, Leonurus artemisia — the same taxon appears under several names. The nomenclatural discussion for this herb was flagged for correction during verification; only the verified facts are shown here, with the details in docs/HERB_NAME_RESEARCH.md.
Tradition · what the text describes
탕액편
The sub-section within this volume has not been verified against the original text yet.
The KTKP traditional materia medica record (M0005968) gives the origin species as Leonurus japonicus Houtt., the part used as 지상부, and the properties as 고신(苦辛), 무독(無毒), 미한(微寒). It lists 간(肝), 방광(膀胱), 심(心), 심포(心包) as the channels entered. The same record cites the Donguibogam (1613) as the source for its indications.
Properties & channel entry: 고신(苦辛), 무독(無毒), 미한(微寒) · 간(肝), 방광(膀胱), 심(心), 심포(心包)
Source species: Leonurus japonicus Houtt. (지상부)
Modern · documented evidence
Postpartum Hemorrhageevidence for this indication
- The indication was derived automatically from the Condition field of 0 registered trial(s). It reflects what is currently being studied, not a traditional use, and a curator should confirm the label is apt.
Literature
SR 3 · RCT 1 · preclinical 4
3 systematic review(s) and 1 RCT(s) were found. Size and consistency are not yet assessed.
Query used
We publish the exact query behind these counts so you can reproduce them yourself.
SRC:MED AND ((TITLE_ABS:"Leonurus japonicus") OR (TITLE_ABS:"Leonurus heterophyllus") OR (TITLE_ABS:"Leonurus artemisia")) AND TITLE_ABS:"Postpartum Hemorrhage"- Coumarins with Different Substituents from Leonurus japonicus Have Opposite Effects on Uterine Smooth Muscle. (2024 · research-article; Journal Article)
- Motherwort synergized with oxytocin for postpartum hemorrhage prevention: Integrated clinical efficacy and mechanism exploration. (2025 · Meta-Analysis; Journal Article)
- Effect of Leonurus japonicus alkaloids on endometrial inflammation and its mechanisms. (2025 · Journal Article)
- Efficacy of carboprost tromethamine combined with leonurus japonicus for prevention of postpartum hemorrhage in high-risk pregnant women: A protocol for systematic review and meta-analysis. (2021 · review-article; Journal Article)
- Leonurus japonicus (Chinese motherwort), an excellent traditional medicine for obstetrical and gynecological diseases: A comprehensive overview. (2019 · Review; Journal Article)
- Alkaloids and flavonoid glycosides from the aerial parts of Leonurus japonicus and their opposite effects on uterine smooth muscle. (2018 · Journal Article)
- Motherwort Injection for Preventing Uterine Hemorrhage in Women With Induced Abortion: A Systematic Review and Meta-Analysis of Randomized Evidence. (2022 · Systematic Review; systematic-review; Journal Article)
- Combining Sprague-Dawley rat uterus cell membrane chromatography with HPLC/MS to screen active components from Leonurus artemisia. (2016 · Research Support, Non-U.S. Gov't; Journal Article)
Clinical trials
- NCT06427980 — NOT_YET_RECRUITING · NA
Uterine Hemorrhageevidence for this indication
- Systematic reviews were found but no RCTs. Check the search query (queryUsed).
- The indication was derived automatically from the Condition field of 0 registered trial(s). It reflects what is currently being studied, not a traditional use, and a curator should confirm the label is apt.
Literature
SR 2 · RCT 0 · preclinical 0
2 systematic review(s) and 0 RCT(s) were found. Size and consistency are not yet assessed.
Query used
We publish the exact query behind these counts so you can reproduce them yourself.
SRC:MED AND ((TITLE_ABS:"Leonurus japonicus") OR (TITLE_ABS:"Leonurus heterophyllus") OR (TITLE_ABS:"Leonurus artemisia")) AND TITLE_ABS:"Uterine Hemorrhage"- Stachydrine: A Systematic Review of Its Multi-Targeted Therapeutic Potential in Cardiovascular, Oncology, Renal, Gynecological, and Inflammatory Disorders. (2026 · Systematic Review; review-article; Journal Article)
- Motherwort Injection for Preventing Uterine Hemorrhage in Women With Induced Abortion: A Systematic Review and Meta-Analysis of Randomized Evidence. (2022 · Systematic Review; systematic-review; Journal Article)
Clinical trials
- NCT06427980 — NOT_YET_RECRUITING · NA
Safety
auto-proposed · unreviewed
- 4 adverse-event or toxicity record(s) were found. This only flags that literature exists — read the abstracts to decide between "caution" and "harm confirmed".
- 1 interaction-related record(s) are retrievable. This flags that literature exists — it is not an interaction checker (§3.4).
- The KTKP record states the following traditional contraindication: 잉부(孕婦)는 복용(服用)을 금(禁)한다.
Adverse-event and toxicity literature
This is not a finding of harm — it lists literature that is retrievable. Read the papers to decide.
- Effect of a Combination of Lactiplantibacillus plantarum KC3 and Leonurus japonicus Extracts in Respiratory Discomfort: A Randomized, Double-Blind, Placebo-Controlled Trial. (2024 · research-article; Multicenter Study; Randomized Controlled Trial; Journal Article)
- Combined Extract of Leonurus japonicus Houtt, Eclipta prostrata L., and Pueraria lobata Ohwi Improved Hot Flashes and Depression in an Ovariectomized Rat Model of Menopause. (2021 · research-article; Journal Article)
- Motherwort Injection for Preventing Uterine Hemorrhage in Women With Induced Abortion: A Systematic Review and Meta-Analysis of Randomized Evidence. (2022 · Systematic Review; systematic-review; Journal Article)
- [Multi-center study of motherwort injection to prevent postpartum hemorrhage after caesarian section]. (2009 · Multicenter Study; Randomized Controlled Trial; Journal Article; English Abstract)
Interaction literature
This lists literature that is retrievable — it is not a judgement that an interaction exists. Read the papers to decide.
Sources
- KTKP materia medica (15002148) (fetched 2026-08-27)
- Europe PMC REST (fetched 2026-08-28)
- ClinicalTrials.gov API v2 (fetched 2026-08-28)
- Europe PMC REST (fetched 2026-08-28)
- ClinicalTrials.gov API v2 (fetched 2026-08-28)
- KTKP materia medica (15002148) (fetched 2026-08-27)
- Europe PMC REST (fetched 2026-08-28)