Amur cork tree 黃柏
Pharmaceutical namePhellodendri Cortex
The three axes are assessed independently and are never combined into a single score.
KTKP records the origin species as Phellodendron amurense Rupr.. It has not yet been cross-checked against the Korean Pharmacopoeia, so the identification confidence is not raised to an official code mapping. The same drug appears under 4 records as name variants. The same source species also yields 2 other separately registered drug(s) (Phellodendri Radix, Phellodendri Caulis), which must not be conflated. The name most used for this taxon in current literature is Phellodendron amurense.
Tradition · what the text describes
탕액편
The sub-section within this volume has not been verified against the original text yet.
The KTKP traditional materia medica record (M0004386) gives the origin species as Phellodendron amurense Rupr., the part used as 껍질, and the properties as 고(苦), 무독(無毒), 한(寒). It lists 대장(大腸), 방광(膀胱), 신(腎) as the channels entered. The same record cites the Donguibogam (1613) as the source for its indications.
Properties & channel entry: 고(苦), 무독(無毒), 한(寒) · 대장(大腸), 방광(膀胱), 신(腎)
Source species: Phellodendron amurense Rupr. (껍질)
Modern · documented evidence
(no indication derived — herb-name-only search)evidence for this indication
- No indication is specified. A and B grades cannot be assigned until the query is narrowed to a specific indication.
- No indication could be derived: no condition appears on two or more registered trials for this herb.
Literature
SR 0 · RCT 4 · preclinical 72
These counts come from a herb-name-only search (0 systematic reviews, 4 RCTs). Without a specific indication they show how much the herb has been studied, not what it works for.
Query used
We publish the exact query behind these counts so you can reproduce them yourself.
SRC:MED AND ((TITLE_ABS:"Phellodendron amurense"))- Lactobacillus Plantarum R-Fermented Phellodendron Amurense Extract Protects Against Pseudorabies Virus by Regulating Oxidative Stress and Inflammation in Vitro and in Vivo. (2026 · Journal Article)
- Exercise and Phellodendron amurense extract differentially impinge on oxidative stress response pathways in a mouse model of prostate cancer. (2026 · research-article; Journal Article)
- Phellodendron amurense Leaf Extract Inhibits Rhabdovirus Infection by Targeting Early Stages of Viral Entry. (2026 · research-article; Journal Article)
- Integrated Transcriptome and Metabolome Analysis Reveals Differential Berberine Biosynthesis in Leaves and Stems of Phellodendron amurense Rupr. Plantlets. (2026 · research-article; Journal Article)
- Two new saprobic species of Helicosporium and Dictyosporium and a new host record of Neohelicomyces guizhouensis isolated from Phellodendron amurense (Rutaceae, Tracheophyta) in China. (2026 · research-article; Journal Article)
- Analysis of a near telomere-to-telomere genome of Phellodendron amurense reveals insights into berberine biosynthesis. (2025 · research-article; Journal Article)
- Comparative Study of Phellodendron amurense Rupr. Components in Alleviating Diabetic Kidney Disease via the PI3K/AKT/GSK-3β/Nrf2 Pathway. (2026 · Journal Article)
- Phellodendron amurense Rupr. Polysaccharides protects against diabetic nephropathy via alteration of PI3K/GSK-3β/Nrf2/TGF-β/Smad signaling pathway and gut microbiota. (2026 · research-article; Journal Article)
- Optimization and antioxidant evaluation of clean and efficient recovery of polyphenols from Phellodendron amurense waste leaves via ultrasound-assisted extraction. (2025 · research-article; Journal Article)
- Evaluating the effects of exercise and phellodendron amurense on cardiac function in a prostate cancer mouse model. (2025 · Research Support, Non-U.S. Gov't; research-article; Journal Article; Research Support, N.I.H., Extramural)
Clinical trials
- NCT01705652 — TERMINATED · PHASE2
- NCT00432484 — COMPLETED · PHASE2
- NCT03728244 — UNKNOWN · PHASE1, PHASE2
- NCT04120597 — COMPLETED · PHASE1, PHASE2
- NCT02737943 — UNKNOWN · PHASE1
- NCT02734251 — COMPLETED · NA
- NCT00676975 — COMPLETED · PHASE2
Safety
auto-proposed · unreviewed
- 4 adverse-event or toxicity record(s) were found. This only flags that literature exists — read the abstracts to decide between "caution" and "harm confirmed".
- 1 interaction-related record(s) are retrievable. This flags that literature exists — it is not an interaction checker (§3.4).
- The KTKP record states the following traditional contraindication: 고한(苦寒)한 약물로 상음패위(傷陰敗胃)시키기 쉬우므로 화왕(火旺)하고 위기(胃氣)가 강한 자(者)가 아니면 복용을 기(忌)한다.
Adverse-event and toxicity literature
This is not a finding of harm — it lists literature that is retrievable. Read the papers to decide.
- Tolerance of Phellodendron amurense bark extract (Nexrutine®) in patients with human prostate cancer. (2015 · Clinical Trial; research-article; Research Support, U.S. Gov't, Non-P.H.S.; Journal Article; Research Support, N.I.H., Extramural)
- Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. (2008 · research-article; Randomized Controlled Trial; Journal Article)
- Phellodendron and Citrus extracts benefit joint health in osteoarthritis patients: a pilot, double-blind, placebo-controlled study. (2009 · research-article; Clinical Trial, Phase I; Randomized Controlled Trial; Journal Article)
- Phellodendron and Citrus extracts benefit cardiovascular health in osteoarthritis patients: a double-blind, placebo-controlled pilot study. (2008 · research-article; Randomized Controlled Trial; Journal Article)
Interaction literature
This lists literature that is retrievable — it is not a judgement that an interaction exists. Read the papers to decide.
- A comparative study on commercial samples of phellodendri cortex. (1993 · Journal Article)
Sources
Bridges from here
- In formulas
- 사백탕 · 신성복기탕 · 자혈양근탕 · 윤폐활담영수탕 · 신기산 · 거풍지보단 · 청신익기탕
- Related patterns
- Vomiting and diarrhea disorder · Pudendal cold disorder · Wind-heat pattern · Dampness-heat pattern · Blood deficiency pattern · Yin deficiency pattern · Qi-blood deficiency pattern · Lung excess patterns · Large intestine excess heat pattern