Thinleaf milkwort 遠志
Pharmaceutical namePolygalae Radix
The three axes are assessed independently and are never combined into a single score.
KTKP records the origin species as Polygala tenuifolia Willd.. It has not yet been cross-checked against the Korean Pharmacopoeia, so the identification confidence is not raised to an official code mapping. The same drug appears under 3 records as name variants. The name most used for this taxon in current literature is Polygala tenuifolia. The nomenclatural discussion for this herb was flagged for correction during verification; only the verified facts are shown here, with the details in docs/HERB_NAME_RESEARCH.md.
Tradition · what the text describes
탕액편
The sub-section within this volume has not been verified against the original text yet.
The KTKP traditional materia medica record (M0002880) gives the origin species as Polygala tenuifolia Willd., the part used as 뿌리, and the properties as 신고(辛苦), 온(溫). It lists 신(腎), 심(心), 폐(肺) as the channels entered. The same record cites the Donguibogam (1613) as the source for its indications.
Properties & channel entry: 신고(辛苦), 온(溫) · 신(腎), 심(心), 폐(肺)
Source species: Polygala tenuifolia Willd. (뿌리)
Modern · documented evidence
Cognitive Impairmentevidence for this indication
- Systematic reviews were found but no RCTs. Check the search query (queryUsed).
- The indication was derived automatically from the Condition field of 3 registered trial(s). It reflects what is currently being studied, not a traditional use, and a curator should confirm the label is apt.
Literature
SR 2 · RCT 0 · preclinical 17
2 systematic review(s) and 0 RCT(s) were found. Size and consistency are not yet assessed.
Query used
We publish the exact query behind these counts so you can reproduce them yourself.
SRC:MED AND ((TITLE_ABS:"Polygala tenuifolia")) AND TITLE_ABS:"Cognitive Impairment"- β-Asarone, Tenuifolin, and YuanZhi Decoction Restore Cognitive Function and Modulate GRIN2B-Associated Autophagy in Alzheimer's Disease. (2026 · Journal Article)
- Traditional Chinese Medicinal Herbs for Treating Post-Ischemic Stroke Cognitive Impairment Insights From Frequency and Association Analysis. (2025 · Systematic Review; review-article; Journal Article)
- Investigation of Kai-Xin-San in alleviating cognitive impairment in aβ transgenic Caenorhabditis elegans through mitochondrial function regulation. (2025 · Journal Article)
- Gut-Brain Axis-Based Polygala Tenuifolia and Magnolia Officinalis Improve D-gal-Induced Cognitive Impairment in Mice Through cAMP and NF-κB Signaling Pathways. (2025 · research-article; Journal Article)
- Tenuigenin ameliorates Alzheimer's disease by targeting MAP2K1: integrated evidence from network pharmacology and experimental validation. (2026 · Research Support, Non-U.S. Gov't; Journal Article)
- Senegenin attenuates LPS-induced neuroinflammation and microglial cell death via Akt phosphorylation and suppression of cGAS-STING-NLRP3 signaling: Network pharmacology and experimental validation. (2026 · Journal Article)
- Polygalacic acid attenuates cognitive impairment by regulating inflammation through PPARγ/NF-κB signaling pathway. (2024 · Research Support, Non-U.S. Gov't; research-article; Journal Article)
- Tenuifolin improves learning and memory by regulating long-term potentiation and dendritic structure of hippocampal CA1 area in healthy female mice but not male mice. (2024 · Research Support, Non-U.S. Gov't; Journal Article)
Clinical trials
- NCT06813274 — NOT_YET_RECRUITING · PHASE2
- NCT02752867 — UNKNOWN · NA
- NCT02641886 — COMPLETED · NA
Major Depressive Disorderevidence for this indication
- 2 registered trial(s) exist but no published systematic review or RCT was found. Check whether the research is ongoing or simply unpublished.
- The indication was derived automatically from the Condition field of 2 registered trial(s). It reflects what is currently being studied, not a traditional use, and a curator should confirm the label is apt.
Literature
SR 0 · RCT 0 · preclinical 1
No human clinical literature found; 1 preclinical (in vitro/animal) record(s) only.
Query used
We publish the exact query behind these counts so you can reproduce them yourself.
SRC:MED AND ((TITLE_ABS:"Polygala tenuifolia")) AND TITLE_ABS:"Major Depressive Disorder"- The Chinese Herbal Formula PAPZ Ameliorates Behavioral Abnormalities in Depressive Mice. (2019 · research-article; Journal Article)
Clinical trials
- NCT03833206 — NOT_YET_RECRUITING · PHASE1, PHASE2
- NCT02395978 — COMPLETED · PHASE2
Alzheimer Diseaseevidence for this indication
- 2 registered trial(s) exist but no published systematic review or RCT was found. Check whether the research is ongoing or simply unpublished.
- The indication was derived automatically from the Condition field of 2 registered trial(s). It reflects what is currently being studied, not a traditional use, and a curator should confirm the label is apt.
Literature
SR 0 · RCT 0 · preclinical 1
No human clinical literature found; 1 preclinical (in vitro/animal) record(s) only.
Query used
We publish the exact query behind these counts so you can reproduce them yourself.
SRC:MED AND ((TITLE_ABS:"Polygala tenuifolia")) AND TITLE_ABS:"Alzheimer Disease"- Induction of NGF synthesis in astrocytes by onjisaponins of Polygala tenuifolia, constituents of kampo (Japanese herbal) medicine, Ninjin-yoei-to. (2003 · Research Support, Non-U.S. Gov't; Journal Article)
Clinical trials
- NCT07768579 — RECRUITING
- NCT03221894 — COMPLETED
Safety
auto-proposed · unreviewed
- 5 adverse-event or toxicity record(s) were found. This only flags that literature exists — read the abstracts to decide between "caution" and "harm confirmed".
- 2 interaction-related record(s) are retrievable. This flags that literature exists — it is not an interaction checker (§3.4).
- The KTKP record states the following traditional contraindication: 심신유화(心腎有火), 음허양항(陰虛陽亢)의 경우에는 기(忌)하며, 궤양병(潰瘍病)과 위염(胃炎)에는 신용(愼用)한다.
Adverse-event and toxicity literature
This is not a finding of harm — it lists literature that is retrievable. Read the papers to decide.
- Magnolia Officinalis Alcohol Extract Alleviates the Intestinal Injury Induced by Polygala Tenuifolia Through Regulating the PI3K/AKT/NF-κB Signaling Pathway and Intestinal Flora. (2024 · research-article; Journal Article)
- Polygala tenuifolia and Acorus tatarinowii in the treatment of Alzheimer's disease: a systematic review and meta-analysis. (2023 · Systematic Review; systematic-review; Journal Article)
- The efficacy and safety of Chinese herbal medicine for mild cognitive impairment: a systematic review and meta-analysis of randomized placebo-controlled trials. (2024 · Systematic Review; systematic-review; Journal Article)
- Effects of Medicinal herb Extracts and their Components on Steatogenic Hepatotoxicity in Sk-hep1 Cells. (2011 · research-article; Journal Article)
- Inhibitory effect of interleukin-1alpha-induced apoptosis by Polygala tenuifolia in Hep G2 cells. (2000 · Research Support, Non-U.S. Gov't; Journal Article)
Interaction literature
This lists literature that is retrievable — it is not a judgement that an interaction exists. Read the papers to decide.
- Integrated Gut Microbiota-Drug Interaction Analysis and Network Pharmacology for the Investigation of Renal-Protective Effect of Polygala tenuifolia Willd. (2025 · research-article; Journal Article)
- Protein unbound pharmacokinetics of ambroxol in the blood and brains of rats and the interaction of ambroxol with Polygala tenuifolia by multiple microdialysis. (2021 · Journal Article)
Sources
- KTKP materia medica (15002148) (fetched 2026-08-27)
- Europe PMC REST (fetched 2026-08-28)
- ClinicalTrials.gov API v2 (fetched 2026-08-28)
- Europe PMC REST (fetched 2026-08-28)
- ClinicalTrials.gov API v2 (fetched 2026-08-28)
- Europe PMC REST (fetched 2026-08-28)
- ClinicalTrials.gov API v2 (fetched 2026-08-28)
- KTKP materia medica (15002148) (fetched 2026-08-27)
- Europe PMC REST (fetched 2026-08-28)
Bridges from here
- In formulas
- 영지원 · 자음건비탕 · 익기안신탕 · 청신해어탕 · 대아교원 · 천왕보심단
- Related patterns
- Heart deficiency patterns · Heart blood deficiency pattern · Phlegm confounding the orifices of the heart pattern · Heart and spleen deficiency pattern