Fo-ti 何首烏
Pharmaceutical namePolygoni Multiflori Radix
The three axes are assessed independently and are never combined into a single score.
KTKP records the origin species as Polygonum multiflorum Thunb.. It has not yet been cross-checked against the Korean Pharmacopoeia, so the identification confidence is not raised to an official code mapping. The same drug appears under 5 records as name variants. The same source species also yields 1 other separately registered drug(s) (Polygoni Multiflori Ramuls), which must not be conflated. The name most used for this taxon in current literature is Polygonum multiflorum. Literature searches for this herb also cover Fallopia multiflora, Reynoutria multiflora, Pleuropterus multiflorus — the same taxon appears under several names. The nomenclatural discussion for this herb was flagged for correction during verification; only the verified facts are shown here, with the details in docs/HERB_NAME_RESEARCH.md.
Tradition · what the text describes
탕액편
The sub-section within this volume has not been verified against the original text yet.
The KTKP traditional materia medica record (M0003312) gives the origin species as Polygonum multiflorum Thunb., the part used as 뿌리, and the properties as 고삽(苦澁), 미온(微溫). It lists 간(肝), 신(腎) as the channels entered. The same record cites the Donguibogam (1613) as the source for its indications.
Properties & channel entry: 고삽(苦澁), 미온(微溫) · 간(肝), 신(腎)
Source species: Polygonum multiflorum Thunb. (뿌리)
Modern · documented evidence
(no indication derived — herb-name-only search)evidence for this indication
- No indication is specified. A and B grades cannot be assigned until the query is narrowed to a specific indication.
- No indication could be derived: no condition appears on two or more registered trials for this herb.
Literature
SR 4 · RCT 3 · preclinical 268
These counts come from a herb-name-only search (4 systematic reviews, 3 RCTs). Without a specific indication they show how much the herb has been studied, not what it works for.
Query used
We publish the exact query behind these counts so you can reproduce them yourself.
SRC:MED AND ((TITLE_ABS:"Polygonum multiflorum") OR (TITLE_ABS:"Fallopia multiflora") OR (TITLE_ABS:"Reynoutria multiflora") OR (TITLE_ABS:"Pleuropterus multiflorus"))- Integrated chemical and genetic authentication of Polygoni Multiflori Caulis: Refuting diameter restrictions and exposing market adulteration. (2026 · Journal Article)
- 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) from Polygonum multiflorum Thunb.: A Systematic Review on Anti-Aging. (2025 · Systematic Review; review-article; Journal Article)
- Identification of potential biomarkers for Polygonum multiflorum-induced liver injury in a clinical cohort: integrating machine learning of metabolomics with transcriptomic profiling. (2026 · Journal Article)
- Bioinspired engineering of Polygonum multiflorum root nanovesicles regulates dermal papilla cells in vitro and stimulates human hair follicle growth ex vivo. (2026 · brief-report; Journal Article)
- Enhancement of ursolic acid (UA), an active ingredient in hawthorn, on the uptake and metabolism of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (THSG) derived from Polygonum multiflorum. (2026 · Journal Article)
- Polysaccharides from Polygonum multiflorum Thunb. and its processed products: A review on traditional uses, extraction, structural characteristics, pharmacological activities, structure-activity relationships, and drug delivery applications. (2026 · Review; Journal Article)
- Therapeutic mechanism of Polygonum multiflorum Thunb. in premature ovarian insufficiency: an integration of network pharmacology, molecular docking, and experimental validation. (2026 · Journal Article)
- [Comparison of clinical characteristics between patients with Polygonum multiflorum-induced liver injury and those with other drug-induced liver injuries]. (2025 · Comparative Study; research-article; Journal Article; English Abstract)
- Regulation mechanism of N2O and CH4 emissions during the pig manure composting amended with Polygonum Multiflorum Thunb. (2026 · Journal Article)
- Metal-Associated Particulate Matter (PM2.5) Induces Cognitive Dysfunction: Polygonum multiflorum Improves Neuroinflammation and Synaptic Function. (2025 · research-article; Journal Article)
Clinical trials
- NCT05008250 — COMPLETED · PHASE4
- NCT07504536 — NOT_YET_RECRUITING · PHASE2
- NCT01549080 — COMPLETED
- NCT00154635 — UNKNOWN · PHASE2
Safety
auto-proposed · unreviewed
- 154 adverse-event or toxicity record(s) were found. This only flags that literature exists — read the abstracts to decide between "caution" and "harm confirmed".
- 1 interaction-related record(s) are retrievable. This flags that literature exists — it is not an interaction checker (§3.4).
- The KTKP record states the following traditional contraindication: 대변당설(大便溏泄) 및 습담(濕痰)의 경우는 적당하지 못하며, 나복(萊菔)을 기(忌)한다.
Adverse-event and toxicity literature
This is not a finding of harm — it lists literature that is retrievable. Read the papers to decide.
- Identification of potential biomarkers for Polygonum multiflorum-induced liver injury in a clinical cohort: integrating machine learning of metabolomics with transcriptomic profiling. (2026 · Journal Article)
- Spatially Resolved Metabolomics and Network Pharmacology Reveal Extract D Nephrotoxicity Mechanisms in Pleuropterus multiflorus Thunb. (2025 · research-article; Journal Article)
- The deglycosylated metabolite of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D- glucoside contributes to immune-mediated hepatotoxicity induced by Polygonum multiflorum. (2025 · Journal Article)
- Common Causes of Drug-Induced Liver Injury in 2025. (2026 · Review; Journal Article)
- Steaming reduces Polygonum multiflorum hepatotoxicity by modulating gut microbiota-bile acid-FXR/NF-κB signaling in the gut-liver axis. (2027 · Journal Article)
Interaction literature
This lists literature that is retrievable — it is not a judgement that an interaction exists. Read the papers to decide.
Sources
Bridges from here
- In formulas
- 각로오수건양단