Rhubarb 大黃
Pharmaceutical nameRhei Radix et Rhizoma
The three axes are assessed independently and are never combined into a single score.
KTKP records the origin species as Rheum palmatum L.. It has not yet been cross-checked against the Korean Pharmacopoeia, so the identification confidence is not raised to an official code mapping. The same source species also yields 1 other separately registered drug(s) (Rhei Rhizoma), which must not be conflated. The name most used for this taxon in current literature is Rheum palmatum.
Tradition · what the text describes
탕액편
The sub-section within this volume has not been verified against the original text yet.
The KTKP traditional materia medica record (M0000511) gives the origin species as Rheum palmatum L., the part used as 뿌리, 뿌리줄기, and the properties as 고(苦), 한(寒). It lists 간(肝), 대장(大腸), 위(胃) as the channels entered. The same record cites the Donguibogam (1613) as the source for its indications.
Properties & channel entry: 고(苦), 한(寒) · 간(肝), 대장(大腸), 위(胃)
Source species: Rheum palmatum L. (뿌리, 뿌리줄기)
Modern · documented evidence
Diabetic Kidney Diseaseevidence for this indication
- 4 registered trial(s) exist but no published systematic review or RCT was found. Check whether the research is ongoing or simply unpublished.
- The indication was derived automatically from the Condition field of 4 registered trial(s). It reflects what is currently being studied, not a traditional use, and a curator should confirm the label is apt.
Literature
SR 0 · RCT 0 · preclinical 1
No human clinical literature found; 1 preclinical (in vitro/animal) record(s) only.
Query used
We publish the exact query behind these counts so you can reproduce them yourself.
SRC:MED AND ((TITLE_ABS:"Rheum palmatum")) AND TITLE_ABS:"Diabetic Kidney Disease"- Tangshenning formula alleviates tubular injury in diabetic kidney disease via the Sestrin2/AMPK/PGC-1α axis: Restoration of mitochondrial function and inhibition of ferroptosis. (2025 · Journal Article)
Clinical trials
- NCT07034807 — NOT_YET_RECRUITING · NA
- NCT00672451 — TERMINATED · PHASE2
- NCT07032116 — NOT_YET_RECRUITING
- NCT06176599 — UNKNOWN · NA
Strokeevidence for this indication
- 3 registered trial(s) exist but no published systematic review or RCT was found. Check whether the research is ongoing or simply unpublished.
- The indication was derived automatically from the Condition field of 3 registered trial(s). It reflects what is currently being studied, not a traditional use, and a curator should confirm the label is apt.
Literature
SR 0 · RCT 0 · preclinical 2
No human clinical literature found; 2 preclinical (in vitro/animal) record(s) only.
Query used
We publish the exact query behind these counts so you can reproduce them yourself.
SRC:MED AND ((TITLE_ABS:"Rheum palmatum")) AND TITLE_ABS:"Stroke"- Mechanistic insights into the multi-target anti-atherosclerotic actions of rhubarb: a traditional remedy revisited. (2025 · review-article; Review; Journal Article)
- Sanhua decoction: Current understanding of a traditional herbal recipe for stroke. (2023 · review-article; Review; Journal Article)
- Rapid characterization of the chemical constituents of Sanhua decoction by UHPLC coupled with Fourier transform ion cyclotron resonance mass spectrometry. (2020 · research-article; Journal Article)
- Application of omics technology to investigate the mechanism underlying the role of San Hua Tang in regulating microglia polarization and blood-brain barrier protection following ischemic stroke. (2023 · Journal Article)
- Network pharmacology-based prediction and validation of the active ingredients and potential mechanisms of the Huangxiong formula for treating ischemic stroke. (2023 · Journal Article)
Clinical trials
- NCT07784569 — NOT_YET_RECRUITING · PHASE3
- NCT04970797 — UNKNOWN
- NCT00569088 — UNKNOWN · PHASE2
Sepsisevidence for this indication
- The indication was derived automatically from the Condition field of 2 registered trial(s). It reflects what is currently being studied, not a traditional use, and a curator should confirm the label is apt.
Literature
SR 0 · RCT 1 · preclinical 3
0 systematic review(s) and 1 RCT(s) were found. Size and consistency are not yet assessed.
Query used
We publish the exact query behind these counts so you can reproduce them yourself.
SRC:MED AND ((TITLE_ABS:"Rheum palmatum")) AND TITLE_ABS:"Sepsis"- [Research progress on action mechanisms of Rheum palmatum anthraquinones in improving acute lung injury]. (2026 · Review; Journal Article; English Abstract)
- Shenhuang Granules for patients with sepsis: study protocol of a multicenter, randomized, double-blind, placebo-controlled clinical trial. (2025 · methods-article; Journal Article)
- Emodin Inhibits NLRP3 Inflammasome Activation and Protects Against Sepsis via Promoting FUNDC1-Mediated Mitophagy. (2025 · research-article; Journal Article)
- [Effects of Yiqi Huoxue Jiedu formula on the gut microbiota in elderly patients with pulmonary-derived sepsis based on 16S rDNA sequencing: a multicenter prospective randomized double-blind controlled trial]. (2025 · Multicenter Study; Randomized Controlled Trial; Journal Article; English Abstract)
- Phylogenomics, phylogeography and germplasms authentication of the Rheum palmatum complex based on complete chloroplast genomes. (2023 · Journal Article)
- UGTs-mediated metabolic interactions contribute to enhanced anti-inflammation activity of Jinhongtang. (2023 · Journal Article)
- Aloe-emodin: A review of its pharmacology, toxicity, and pharmacokinetics. (2020 · Review; Journal Article)
- Emodin improves lipopolysaccharide-induced microcirculatory disturbance in rat mesentery. (2013 · Research Support, Non-U.S. Gov't; Journal Article)
Clinical trials
- NCT03048903 — UNKNOWN · PHASE2
- NCT06514339 — RECRUITING · EARLY_PHASE1
Safety
auto-proposed · unreviewed
- 25 adverse-event or toxicity record(s) were found. This only flags that literature exists — read the abstracts to decide between "caution" and "harm confirmed".
- 6 interaction-related record(s) are retrievable. This flags that literature exists — it is not an interaction checker (§3.4).
- The KTKP record states the following traditional contraindication: 표증미해자(表證未解者), 혈허기약(血虛氣弱), 비위허한(脾胃虛寒), 무실열적체자(無實熱積滯者) 및태전산후(胎前産後)에는 복용을 기(忌)한다.
Adverse-event and toxicity literature
This is not a finding of harm — it lists literature that is retrievable. Read the papers to decide.
- Hepatotoxicity prediction for traditional Chinese medicine: a two-step in silico framework integrating network and machine learning approaches. (2026 · research-article; Journal Article)
- Optimized therapeutic potential of Yinchenhao decoction for cholestatic hepatitis by combined network meta-analysis and network pharmacology. (2024 · Network Meta-Analysis; Journal Article)
- Application of Chemometric Analysis With Acute Toxicity Tests of Zebrafish and Network Pharmacology for Comparison of Different Species: Rhubarb as an Example. (2025 · Comparative Study; Journal Article)
- Study on the Hepatotoxicity of Emodin and Its Application in the Treatment of Liver Fibrosis. (2024 · research-article; Journal Article)
- Shenhuang Granules for patients with sepsis: study protocol of a multicenter, randomized, double-blind, placebo-controlled clinical trial. (2025 · methods-article; Journal Article)
Interaction literature
This lists literature that is retrievable — it is not a judgement that an interaction exists. Read the papers to decide.
- Hepatotoxicity prediction for traditional Chinese medicine: a two-step in silico framework integrating network and machine learning approaches. (2026 · research-article; Journal Article)
- Acute and Chronic Administrations of Rheum palmatum Reduced the Bioavailability of Phenytoin in Rats: A New Herb-Drug Interaction. (2012 · research-article; Journal Article)
- The Influence of Aconitum carmichaelii Debx. on the Pharmacokinetic Characteristics of Main Components in Rheum palmatum L. (2015 · Research Support, Non-U.S. Gov't; Journal Article)
- San-Huang-Xie-Xin-Tang Constituents Exert Drug-Drug Interaction of Mutual Reinforcement at Both Pharmacodynamics and Pharmacokinetic Level: A Review. (2016 · review-article; Review; Journal Article)
- Effect of the water extract and ethanol extract from traditional Chinese medicines Angelica sinensis (Oliv.) Diels, Ligusticum chuanxiong Hort. and Rheum palmatum L. on rat liver cytochrome P450 activity. (2006 · Research Support, Non-U.S. Gov't; Journal Article)
Sources
- KTKP materia medica (15002148) (fetched 2026-08-27)
- Europe PMC REST (fetched 2026-08-28)
- ClinicalTrials.gov API v2 (fetched 2026-08-28)
- Europe PMC REST (fetched 2026-08-28)
- ClinicalTrials.gov API v2 (fetched 2026-08-28)
- Europe PMC REST (fetched 2026-08-28)
- ClinicalTrials.gov API v2 (fetched 2026-08-28)
- KTKP materia medica (15002148) (fetched 2026-08-27)
- Europe PMC REST (fetched 2026-08-28)
Bridges from here
- In formulas
- 무극환