Schisandra 五味子
Pharmaceutical nameSchizandrae Fructus
The three axes are assessed independently and are never combined into a single score.
KTKP records the origin species as Schizandra chinensis (Turcz.) Baill. (= Maximowiczia sinensis Rupr). It has not yet been cross-checked against the Korean Pharmacopoeia, so the identification confidence is not raised to an official code mapping. The same drug appears under 3 records as name variants. The name most used for this taxon in current literature is Schisandra chinensis. Literature searches for this herb also cover Schizandra chinensis — the same taxon appears under several names.
Tradition · what the text describes
탕액편
The sub-section within this volume has not been verified against the original text yet.
The KTKP traditional materia medica record (M0002636) gives the origin species as Schizandra chinensis (Turcz.) Baill. (= Maximowiczia sinensis Rupr), the part used as 열매, and the properties as 무독(無毒), 산감(酸甘), 온(溫). It lists 신(腎), 심(心), 폐(肺) as the channels entered. The same record cites the Donguibogam (1613) as the source for its indications.
Properties & channel entry: 무독(無毒), 산감(酸甘), 온(溫) · 신(腎), 심(心), 폐(肺)
Source species: Schizandra chinensis (Turcz.) Baill. (= Maximowiczia sinensis Rupr) (열매)
Modern · documented evidence
Obesityevidence for this indication
- The indication was derived automatically from the Condition field of 2 registered trial(s). It reflects what is currently being studied, not a traditional use, and a curator should confirm the label is apt.
Literature
SR 1 · RCT 1 · preclinical 10
1 systematic review(s) and 1 RCT(s) were found. Size and consistency are not yet assessed.
Query used
We publish the exact query behind these counts so you can reproduce them yourself.
SRC:MED AND ((TITLE_ABS:"Schisandra chinensis") OR (TITLE_ABS:"Schizandra chinensis")) AND TITLE_ABS:"Obesity"- Schisandra chinensis Bee Pollen Extract Alleviates Obesity by Modulating Gut Microbiota-Driven Bile Acid Metabolism. (2025 · research-article; Journal Article)
- Schisantherin A interacts with gut bacteria to stimulate adipose tissue thermogenesis in obese mice via a TGR5‒p-CREB‒STAT6 signaling pathway. (2025 · research-article; Journal Article)
- Fruit of Schisandra chinensis and its bioactive component schizandrin B ameliorate obesity-induced skeletal muscle atrophy. (2022 · Research Support, Non-U.S. Gov't; Journal Article)
- A simple and effective method based on enzyme-ligand complex for affinity analysis of lipase inhibitor from Schisandra chinensis (Turcz.) Baill. (2022 · Journal Article)
- Changes in the Gut Microbiota after the Use of Herbal Medicines in Overweight and Obese Individuals: A Systematic Review. (2023 · Systematic Review; review-article; Journal Article)
- Schisandrin C isolated from Schisandra chinensis fruits inhibits lipid accumulation by regulating adipogenesis and lipolysis through AMPK signaling in 3T3-L1 adipocytes. (2022 · Research Support, Non-U.S. Gov't; Journal Article)
- Anti-Obesity Effect of α-Cubebenol Isolated from Schisandra chinensis in 3T3-L1 Adipocytes. (2021 · research-article; Journal Article)
- Anti-Cancer Effects of α-Cubebenoate Derived from Schisandra chinensis in CT26 Colon Cancer Cells. (2022 · research-article; Journal Article)
Clinical trials
- NCT02185638 — COMPLETED · NA
- NCT02298426 — COMPLETED · NA
Safety
auto-proposed · unreviewed
- 53 adverse-event or toxicity record(s) were found. This only flags that literature exists — read the abstracts to decide between "caution" and "harm confirmed".
- 12 interaction-related record(s) are retrievable. This flags that literature exists — it is not an interaction checker (§3.4).
- The KTKP record states the following traditional contraindication: 표사(表邪)가 미해(未解)되었거나 실열(實熱)에 속하였을 때, 또한 해수초기(咳嗽初起)와 마진초발(麻疹初發) 등의 병증(病證)에는 모두 적당하지 못하다.
Adverse-event and toxicity literature
This is not a finding of harm — it lists literature that is retrievable. Read the papers to decide.
- [Severe Intracranial Hemorrhage Secondary to Hemorrhagic Diathesis Following the Use of a Tablet Containing Schisandra Chinensis: A Case Report]. (2025 · Journal Article; English Abstract; Case Reports)
- The protective effect of Schisandra lignans on the hepatotoxicity induced by the metabolic activation of dictamnine. (2025 · Journal Article)
- Schisandrin B alleviates sulfolane-induced liver injury via the APOA1/ROS/NF-κB signaling pathway. (2026 · Journal Article)
- Ameliorative effect of Schisandrol B against Diosbulbin B-induced hepatotoxicity via inhibiting CYP3A4-mediated bioactivation. (2024 · Research Support, Non-U.S. Gov't; Journal Article)
- A supercritical oil extract of Schisandra chinensis seeds ameliorates Huntington's disease-like symptoms and neuropathology: the potential role of anti-oxidant and anti-inflammatory effects. (2024 · research-article; Journal Article)
Interaction literature
This lists literature that is retrievable — it is not a judgement that an interaction exists. Read the papers to decide.
- Inhibition of human CYP3A4 and CYP3A5 enzymes by gomisin C and gomisin G, two lignan analogs derived from Schisandra chinensis. (2017 · research-article; Journal Article)
- Inhibition of UDP-Glucuronosyltransferases (UGTs) Activity by constituents of Schisandra chinensis. (2015 · Research Support, Non-U.S. Gov't; research-article; Journal Article)
- Multifaceted interaction of the traditional Chinese medicinal herb Schisandra chinensis with cytochrome P450-mediated drug metabolism in rats. (2014 · Research Support, Non-U.S. Gov't; Journal Article)
- Pharmacokinetic herb-drug interactions (part 2): drug interactions involving popular botanical dietary supplements and their clinical relevance. (2012 · Review; Journal Article)
- Inhibitory Effects of Schisandra Lignans on Cytochrome P450s and Uridine 5'-Diphospho-Glucuronosyl Transferases in Human Liver Microsomes. (2021 · research-article; Journal Article)
Sources
Bridges from here
- In formulas
- 대온경탕