Bupleurum 柴胡
Pharmaceutical nameBupleuri Radix
The three axes are assessed independently and are never combined into a single score.
KTKP records the origin species as Bupleurum falcatum Linne. It has not yet been cross-checked against the Korean Pharmacopoeia, so the identification confidence is not raised to an official code mapping. The same drug appears under 2 records as name variants. The name most used for this taxon in current literature is Bupleurum falcatum.
Tradition · what the text describes
탕액편
The sub-section within this volume has not been verified against the original text yet.
The KTKP traditional materia medica record (M0002261) gives the origin species as Bupleurum falcatum Linne, the part used as 뿌리, and the properties as 고(苦), 무독(無毒), 미한(微寒). It lists 간(肝), 담(膽) as the channels entered. The same record cites the Donguibogam (1613) as the source for its indications.
Properties & channel entry: 고(苦), 무독(無毒), 미한(微寒) · 간(肝), 담(膽)
Source species: Bupleurum falcatum Linne (뿌리)
Modern · documented evidence
Irritable Bowel Syndromeevidence for this indication
- 2 registered trial(s) exist but no published systematic review or RCT was found. Check whether the research is ongoing or simply unpublished.
- The indication was derived automatically from the Condition field of 2 registered trial(s). It reflects what is currently being studied, not a traditional use, and a curator should confirm the label is apt.
Literature
SR 0 · RCT 0 · preclinical 0
No human studies were found within the sources searched. This means "not yet studied", not "does not work".
Query used
We publish the exact query behind these counts so you can reproduce them yourself.
SRC:MED AND ((TITLE_ABS:"Bupleurum falcatum")) AND TITLE_ABS:"Irritable Bowel Syndrome"Clinical trials
- NCT02653937 — COMPLETED · NA
- NCT00676975 — COMPLETED · PHASE2
Safety
auto-proposed · unreviewed
- 4 adverse-event or toxicity record(s) were found. This only flags that literature exists — read the abstracts to decide between "caution" and "harm confirmed".
- The KTKP record states the following traditional contraindication: 성(性)이 승발(升發)하므로 허인(虛人)의 기역(氣逆)이나 혹은 음허화왕(陰虛火旺), 진음휴손자(眞陰虧損者)와 간양상승자(肝陽上升者)는 복용(服用)을 기(忌)한다.
Adverse-event and toxicity literature
This is not a finding of harm — it lists literature that is retrievable. Read the papers to decide.
- Activation of Fas death receptor pathway and Bid in hepatocytes is involved in saikosaponin D induction of hepatotoxicity. (2016 · Research Support, Non-U.S. Gov't; Journal Article)
- Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling. (2014 · research-article; Journal Article)
- Saikosaponin-d-mediated downregulation of neurogenesis results in cognitive dysfunction by inhibiting Akt/Foxg-1 pathway in mice. (2018 · Journal Article)
- Oleanene glycosides of the aerial parts and seeds of Bupleurum falcatum and the aerial parts of Bupleurum rotundifolium, and their evaluation as anti-hepatitis agents. (2011 · Journal Article)
Sources
Bridges from here
- In formulas
- 당귀작약탕 · 신성복기탕 · 삼호온담탕 · 시호계지탕 · 시호방귀탕 · 대온경탕 · 반하후박탕 · 우황청심원 · 형개연교탕
- Related patterns
- Neck stiffness disorder · Food retention disorder · Vomiting and diarrhea disorder · Pudendal cold disorder · Yang collapse pattern · Middle qi sinking pattern · Lung excess patterns · Heart and gallbladder qi deficiency pattern