Licorice 甘草
Pharmaceutical nameGlycyrrhizae Radix
The three axes are assessed independently and are never combined into a single score.
KTKP records the origin species as Glycyrrhiza uralensis Fisch.. It has not yet been cross-checked against the Korean Pharmacopoeia, so the identification confidence is not raised to an official code mapping. The same drug appears under 6 records as name variants. The same source species also yields 3 other separately registered drug(s) (Glycyrrhizae Praeparatus Pulvis, Glycyrrhizae Radicii Virgula, Glycyrrhizae Radix Praeparata), which must not be conflated. The name most used for this taxon in current literature is Glycyrrhiza uralensis. Literature searches for this herb also cover Glycyrrhizae uralensis — the same taxon appears under several names. The nomenclatural discussion for this herb was flagged for correction during verification; only the verified facts are shown here, with the details in docs/HERB_NAME_RESEARCH.md.
Tradition · what the text describes
탕액편
The sub-section within this volume has not been verified against the original text yet.
The KTKP traditional materia medica record (M0000073) gives the origin species as Glycyrrhiza uralensis Fisch., the part used as 뿌리, and the properties as 감(甘), 평(平). It lists 비(脾), 심(心), 위(胃), 폐(肺) as the channels entered. The same record cites the Donguibogam (1613) as the source for its indications.
Properties & channel entry: 감(甘), 평(平) · 비(脾), 심(心), 위(胃), 폐(肺)
Source species: Glycyrrhiza uralensis Fisch. (뿌리)
Modern · documented evidence
Irritable Bowel Syndromeevidence for this indication
- 2 registered trial(s) exist but no published systematic review or RCT was found. Check whether the research is ongoing or simply unpublished.
- The indication was derived automatically from the Condition field of 2 registered trial(s). It reflects what is currently being studied, not a traditional use, and a curator should confirm the label is apt.
Literature
SR 0 · RCT 0 · preclinical 0
No human studies were found within the sources searched. This means "not yet studied", not "does not work".
Query used
We publish the exact query behind these counts so you can reproduce them yourself.
SRC:MED AND ((TITLE_ABS:"Glycyrrhiza uralensis") OR (TITLE_ABS:"Glycyrrhizae uralensis")) AND TITLE_ABS:"Irritable Bowel Syndrome"- Anti‑inflammatory and antioxidant activity of the traditional herbal formula Gwakhyangjeonggi‑san via enhancement of heme oxygenase‑1 expression in RAW264.7 macrophages. (2016 · Journal Article)
Clinical trials
- NCT02653937 — COMPLETED · NA
- NCT00676975 — COMPLETED · PHASE2
Cardiovascular Diseasesevidence for this indication
- 2 registered trial(s) exist but no published systematic review or RCT was found. Check whether the research is ongoing or simply unpublished.
- The indication was derived automatically from the Condition field of 2 registered trial(s). It reflects what is currently being studied, not a traditional use, and a curator should confirm the label is apt.
Literature
SR 0 · RCT 0 · preclinical 1
No human clinical literature found; 1 preclinical (in vitro/animal) record(s) only.
Query used
We publish the exact query behind these counts so you can reproduce them yourself.
SRC:MED AND ((TITLE_ABS:"Glycyrrhiza uralensis") OR (TITLE_ABS:"Glycyrrhizae uralensis")) AND TITLE_ABS:"Cardiovascular Diseases"- Detoxification and benefits on acute heart failure in mice- of fuziline using glycyrrhetinic acid: an integrated biochemical analysis. (2024 · research-article; Journal Article)
- Screening of anti-heart failure active compounds from fangjihuangqi decoction in verapamil-induced zebrafish model by anti-heart failure index approach. (2022 · research-article; Journal Article)
- Effect of Chinese Herbal Medicine Therapy on Risks of Overall, Diabetes-Related, and Cardiovascular Diseases-Related Mortalities in Taiwanese Patients With Hereditary Hemolytic Anemias. (2022 · research-article; Journal Article)
- In silico Approach for Anti-Thrombosis Drug Discovery: P2Y1R Structure-Based TCMs Screening. (2016 · research-article; Journal Article)
- Development and validation of an high-performance liquid chromatography-diode array detector method for the simultaneous determination of six phenolic compounds in abnormal savda munziq decoction. (2015 · research-article; Journal Article)
- Effect of Si-Miao-Yong-An on the stability of atherosclerotic plaque in a diet-induced rabbit model. (2012 · Research Support, Non-U.S. Gov't; Journal Article)
Clinical trials
- NCT03027375 — UNKNOWN · PHASE2
- NCT07048158 — RECRUITING · NA
Safety
auto-proposed · unreviewed
- This signal was read off the NCCIH text by keyword rules. A curator must read the source and confirm it.
- The NCCIH page deals mainly with G. glabra rather than this species.
- The KTKP record states the following traditional contraindication: 대극(大戟), 원화(芫花), 감수(甘遂)와 같이 쓰면 안 됨.
- NCCIH states: · Licorice contains a component called glycyrrhizin, or glycyrrhizic acid, that can cause serious adverse effects, such as irregular heartbeat and cardiac arrest, especially when consumed in large amounts or in the long term.
- NCCIH states: Even small amounts of glycyrrhizin from licorice root products have been linked to severe adverse effects in people who consume a lot of salt, in people with hypertension, and in people with heart or kidney conditions.
- NCCIH states: · Consuming oral licorice extract in large amounts (about 250 grams of licorice per week) during pregnancy is unsafe and can increase the risk of delivery before gestational age of 38 weeks.
- NCCIH states: Little is known about whether it is safe to use licorice while breastfeeding.
Adverse-event and toxicity literature
This is not a finding of harm — it lists literature that is retrievable. Read the papers to decide.
- Precision treatment and frontier advances of glycyrrhizin preparations in drug-induced liver injury (DILI). (2026 · Review; Journal Article)
- Protective Effects of Licorice (Glycyrrhiza uralensis) Against Vancomycin-Induced Nephrotoxicity In Vivo and In Vitro. (2026 · research-article; Journal Article)
- Network Pharmacology Reveals the Mechanism of Sini Decoction Against Aconitum carmichaelii Debeaux-Induced Cardiotoxicity. (2026 · Journal Article)
- Glycyrrhizin preparations in liver diseases: a narrative review of mechanisms and therapeutic potential. (2026 · review-article; Review; Journal Article)
- The Development of Immunological Quantification Method for Glycyrrhetinic Acid in Serum to Estimate the Potential Risk for Pseudoaldsteronism. (2026 · Journal Article)
Interaction literature
This lists literature that is retrievable — it is not a judgement that an interaction exists. Read the papers to decide.
- Herb-Drug Interaction Potential of Licorice Extract and Paclitaxel: A Pharmacokinetic Study in Rats. (2020 · Validation Study; Journal Article)
- Simultaneous determination of five minor coumarins and flavonoids in Glycyrrhiza uralensis by solid-phase extraction and high-performance liquid chromatography/electrospray ionization tandem mass spectrometry. (2014 · Research Support, Non-U.S. Gov't; Journal Article)
- Liquorice, a unique "guide drug" of traditional Chinese medicine: a review of its role in drug interactions. (2013 · Research Support, Non-U.S. Gov't; Review; Journal Article)
- Study on the pharmacokinetics drug-drug interaction potential of Glycyrrhiza uralensis, a traditional Chinese medicine, with lidocaine in rats. (2009 · Research Support, Non-U.S. Gov't; Journal Article)
Sources
- KTKP materia medica (15002148) (fetched 2026-08-27)
- Europe PMC REST (fetched 2026-08-28)
- ClinicalTrials.gov API v2 (fetched 2026-08-28)
- Europe PMC REST (fetched 2026-08-28)
- ClinicalTrials.gov API v2 (fetched 2026-08-28)
- KTKP materia medica (15002148) (fetched 2026-08-27)
- NCCIH Herbs at a Glance (fetched 2026-08-27)
Bridges from here
- In formulas
- 계령탕 · 계출탕 · 당귀작약탕 · 성비산 · 실장산 · 오증탕 · 자음건비탕 · 지축이진탕 · 청화활담환 · 호골산 · 경험이방음 · 계마각반탕 · 당귀사역탕 · 신성복기탕 · 오복화독단 · 삼호온담탕 · 시호계지탕 · 육울탕 · 아교산 · 양혈거풍탕 · 사순청량음 · 조기산 · 익기안신탕 · 갈근죽여탕 · 자혈양근탕 · 청신해어탕 · 당귀윤조탕 · 윤폐활담영수탕 · 승준환 · 방풍천마산 · 신기산 · 사수음 · 거풍지보단 · 오격관중산 · 침향강기산 · 생료오적산 · 시호방귀탕 · 청신익기탕 · 내탁천금산 · 대온경탕 · 단삼음자 · 일복산 · 삼화오자환 · 곽향정기산 · 반하후박탕 · 방풍통성산 · 우황청심원 · 형개연교탕 · 십육미류기음 · 분심기음
- Related patterns
- Maehaekqi · Depressive disorder · Wilting disorder · Neck stiffness disorder · Joint-running wind disorder · Crane-knee arthritis disorder · Food retention disorder · Vomiting and diarrhea disorder · Block and repulsion disorder · Pudendal cold disorder · Wind-cold pattern · Wind-heat pattern · Wind-dampness pattern · Cold-dampness pattern · Dampness-heat pattern · Early yang stage pattern · Late yin stage pattern · Qi phase pattern · Blood phase pattern · Qi patterns · Qi deficiency pattern · Qi stagnation pattern · Qi uprising pattern · Blood deficiency pattern · Blood dryness pattern · Blood heat pattern · Yin deficiency pattern · Yang collapse pattern · Qi-blood deficiency pattern · Liver deficiency patterns · Heart deficiency patterns · Phlegm confounding the orifices of the heart pattern · Spleen qi deficiency pattern · Middle qi sinking pattern · Lung deficiency patterns · Lung excess patterns · Gallbladder heat pattern · Stomach heat pattern · Large intestine deficiency cold pattern · Heart and gallbladder qi deficiency pattern · Heart and spleen deficiency pattern